| Autor: |
Zaidman, A. M., Korel, A. V., Shevchenko, A. I., Shchelkunova, E. I., Sherman, K. M., Predein, u. A., Kosareva, O. S. |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2016, Vol. 1760 Issue 1, p1-5, 5p, 2 Color Photographs |
| Abstrakt: |
Creating tissue-engineering constructs based on the mechanism of cartilage-bone evolution is promising for traumatology and orthopedics. Such a graft was obtained from a chondrograft by transdifferentiation. The hondrograft placed in osteogenic medium is undergoing osteogenic differentiation for 14-30 days. Tissue specificity of the osteograft was studied by morphology, immunohistochemistry, electron microscopy, and the expression of the corresponding genes was estimated. The expression of osteonectin, fibronectin, collagen of type I, izolektin and CD 44 is determined. Alkaline phosphatase and matrix vesicles are determined in osteoblasts. Calcificates are observed in the matrix. Chondrogenic proteins expression is absent. These findings evidence the tissue specificity of the developed osteograft. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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