Ca2+ Channels as Targets of Neurological Disease: Lambert–Eaton Syndrome and Other Ca2+ Channelopathies.

Autor:	Flink, Michael T., Atchison, William D.
Předmět:	CALCIUM channels NEUROTRANSMITTERS NEUROMUSCULAR diseases MYASTHENIA gravis CHOLINERGIC mechanisms ION channels
Zdroj:	Journal of Bioenergetics & Biomembranes; Dec2003, Vol. 35 Issue 6, p697-718, 22p, 11 Diagrams
Abstrakt:	Points out that in the nervous system, voltage-gated calcium channels regulate numerous processes critical to neuronal function including secretion of neurotransmitters, initiation of action potentials in dendritic regions of some neurons, growth cone elongation, and gene expression. Observation that autoimmune attack on calcium channels at motor axon terminals causes peripheral cholinergic nerve dysfunction observed in Lambert-Eaton Myasthenic Syndrome (LEMS); Models of LEMS.
Databáze:	Complementary Index
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