| Autor: |
Kitajima, Toshiyuki, Imamura, Sadao |
| Předmět: |
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| Zdroj: |
Experimental Dermatology; Aug93, Vol. 2 Issue 4, p154-156, 3p |
| Abstrakt: |
Whole body ultraviolet light (UV) radiation causes systemic immunosuppression. Splenic antigen-presenting cell (APC) activity is decreased by UV radiation. To determine whether splenic CD4[sup+] or CD8[sup+] cells are involved in the UV- induced depression of splenic alloantigen- presenting function, we investigated the effect of in vivo UV radiation on the splenic stimulatory function in allogeneic mixed in mice after the elimination of CD4[sup+] or CD8[sup+] cells by administering anti-CD8 or anti-CD4 Ab. Ab-treated and non-treated mice were exposed to UVB radiation (2.5 kJ/m[sup2) twice or eight times. Two exposures to UVB radiation significantly suppressed the splenic alloantigen-presenting function of mice previously treated with anti-CD4 Ab, but hardly affected that of anti-CD8 Ab-treated or non-treated mice 2 days after the last radiation. On the other hand, eight exposures to UV8 radiation suppressed this function in all mice. FACS analysis revealed that the UV-induced suppression is not, associated with a significant decrease in the number of IA[sup+] cell, as stimulator cells. It is suggested that CD4[sup+] cells are somewhat preventive of the UV-induced depression of splenic alloantigen-presenting function. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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