Synthesis of Trifluoromethyl-Substituted Ethyl Picolinate Derivatives by the Cobalt-Catalyzed Regioselective Intermolecular [2+2+2] Cycloaddition.

Autor:	Tomoki Ishikawa, Taro Sonehara, Shogo Murakami, Maki Minakawa, Motoi Kawatsura
Předmět:	COBALT FERROMAGNETIC materials CHEMICAL synthesis RING formation (Chemistry) ALKYNES REGIOSELECTIVITY (Chemistry)
Zdroj:	Synlett; 2016, Vol. 27 Issue 13, p2029-2033, 5p
Abstrakt:	We demonstrated the intermolecular [2+2+2] cycloaddition of aryl- and trifluoromethyl-substituted internal alkyne and ethyl cyanoformate, and succeeded in constructing the pyridine derivatives using the CoI2/dcype/Zn catalyst system. The reaction proceeded with a high regioselectivity, and two trifluoromethyl-substituted ethyl picolinate derivatives were obtained as a single regioisomer. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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