Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry.

Autor: Giampà, M., Lissel, M. B., Patschkowski, T., Fuchser, J., Hans, V. H., Gembruch, O., Bednarz, H., Niehaus, K.
Předmět:
Zdroj: Chemical Communications; 8/14/2016, Vol. 52 Issue 63, p9801-9804, 4p
Abstrakt: A novel vacuum stable proton sponge, 4-maleicanhydridoproton sponge (MAPS), was prepared and applied as the matrix in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) of an aggressive brain tumor tissue (glioblastoma multiforme). Ionic maps of lactate, 2-hydroxyglutarate and chloride anions (m/z 89, 147, 35, respectively) were obtained using a routine MALDI ToF mass spectrometer. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index