| Autor: |
Viswanath, A., Keerthana, B., Bindu, G. Hima, Rani, B. Sudha, Babu, P. Srinivasa |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutical, Chemical & Biological Sciences; Apr-Jun2016, Vol. 6 Issue 2, p215-221, 7p |
| Abstrakt: |
Benzimidazoles are replaced with a variety of pharmacological activities like anti-hypertensive, antitumor, anti-helmintic along with anti-microbial activity. In this we synthesize various benzimidazole derivatives with the substitution of second position. Ortho phenylenediamine is treated with different substituted aromatic aldehydes in the presence of p-toluene sulphonic acid catalyst. P-TsOHwas used to be a catalyst for the synthesis of 2-arylsubstituted benzimidazoles efficiently. Simple and convenient procedure, easy purification and shorter reaction time are the advantageous features of this method. These synthesized compounds showed significant activity against Gram +ve& Gramve Bacteria. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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