| Autor: |
Beghé, B., Padoan, M., Moss, C.T., Barton, S.J., Holloway, J.W., Holgate, S.T., Howell, W.M., Mapp, C.E. |
| Předmět: |
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| Zdroj: |
Allergy; Jan2004, Vol. 59 Issue 1, p61-64, 4p |
| Abstrakt: |
Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5–15% of the exposed population suggesting an underlying genetic susceptibility. To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)- α A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects. Neither the distribution of HLA class I antigens nor the distribution of TNF- α A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects. These results suggest that HLA class I antigens and TNF- α A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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