| Autor: |
Chao Pang, van Enckevort, David, de Haan, Mark, Kelpin, Fleur, Jetten, Jonathan, Hendriksen, Dennis, de Boer, Tommy, Charbon, Bart, Winder, Erwin, van der Velde, K. Joeri, Doiron, Dany, Fortier, Isabel, Hillege, Hans, Swertz, Morris A. |
| Předmět: |
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| Zdroj: |
Bioinformatics; 7/15/2016, Vol. 32 Issue 14, p2176-2183, 8p |
| Abstrakt: |
Motivation: While the size and number of biobanks, patient registries and other data collections are increasing, biomedical researchers still often need to pool data for statistical power, a task that requires time-intensive retrospective integration. Results: To address this challenge, we developed MOLGENIS/connect, a semi-automatic system to find, match and pool data from different sources. The system shortlists relevant source attributes from thousands of candidates using ontology-based query expansion to overcome variations in terminology. Then it generates algorithms that transform source attributes to a common target DataSchema. These include unit conversion, categorical value matching and complex conversion patterns (e.g. calculation of BMI). In comparison to human-experts, MOLGENIS/connect was able to auto-generate 27% of the algorithms perfectly, with an additional 46% needing only minor editing, representing a reduction in the human effort and expertise needed to pool data. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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