Statin use and all-cancer survival: prospective results from the Women's Health Initiative.

Autor: Wang, Ange, Aragaki, Aaron K, Tang, Jean Y, Kurian, Allison W, Manson, JoAnn E, Chlebowski, Rowan T, Simon, Michael, Desai, Pinkal, Wassertheil-Smoller, Sylvia, Liu, Simin, Kritchevsky, Stephen, Wakelee, Heather A, Stefanick, Marcia L
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Zdroj: British Journal of Cancer; 6/28/2016, Vol. 115 Issue 1, p129-135, 7p, 3 Charts
Abstrakt: Background: This study aims to investigate the association between statin use and all-cancer survival in a prospective cohort of postmenopausal women, using data from the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT).Methods: The WHI study enrolled women aged 50-79 years from 1993 to 1998 at 40 US clinical centres. Among 146 326 participants with median 14.6 follow-up years, 23 067 incident cancers and 3152 cancer deaths were observed. Multivariable-adjusted Cox proportional hazards models were used to investigate the relationship between statin use and cancer survival.Results: Compared with never-users, current statin use was associated with significantly lower risk of cancer death (hazard ratio (HR), 0.78; 95% confidence interval (CI), 0.71-0.86, P<0.001) and all-cause mortality (HR, 0.80; 95% CI, 0.74-0.88). Use of other lipid-lowering medications was also associated with increased cancer survival (P-interaction (int)=0.57). The lower risk of cancer death was not dependent on statin potency (P-int=0.22), lipophilicity/hydrophilicity (P-int=0.43), type (P-int=0.34) or duration (P-int=0.33). However, past statin users were not at lower risk of cancer death compared with never-users (HR, 1.06; 95% CI, 0.85-1.33); in addition, statin use was not associated with a reduction of overall cancer incidence despite its effect on survival (HR, 0.96; 95% CI, 0.92-1.001).Conclusions: In a cohort of postmenopausal women, regular use of statins or other lipid-lowering medications was associated with decreased cancer death, regardless of the type, duration, or potency of statin medications used. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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