Incidence of contrast-induced acute kidney injury in a pediatric setting: a cohort study.
| Autor: | Cantais, Aymeric, Hammouda, Zeineb, Mory, Olivier, Patural, Hugues, Stephan, Jean-Louis, Gulyaeva, Lyudmyla, Darmon, Michael |
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| Předmět: |
ACADEMIC medical centers
ACUTE kidney failure CHI-squared test COMPUTED tomography CONFIDENCE intervals EXPERIMENTAL design FISHER exact test INTRAVENOUS therapy KIDNEYS SCIENTIFIC observation PROBABILITY theory RESEARCH funding LOGISTIC regression analysis CONTRAST media RETROSPECTIVE studies DATA analysis software DESCRIPTIVE statistics ODDS ratio MANN Whitney U Test DRUG administration DRUG dosage DISEASE risk factors |
| Zdroj: | Pediatric Nephrology; Aug2016, Vol. 31 Issue 8, p1355-1362, 8p, 3 Charts, 1 Graph |
| Abstrakt: | Background: Contrast-induced acute kidney injury (CI-AKI) is a common pathology among adult patients, with an incidence ranging from 3-25 % depending on risk factors. Little information is available regarding CI-AKI incidence, risk factors, and prognostic impact in the pediatric population. Methods: We performed a retrospective study of pediatric patients who underwent computed tomography (CT) scan with iodinated contrast media injection between 2005 and 2014 in five pediatric units of a university hospital. CI-AKI was defined according to Kidney Disease/Improving Global Outcomes (KDIGO) criteria. Results: Of 346 identified patients, 233 had renal function follow-up and were included in our analyses. CI-AKI incidence was 10.3 % [95 % confidence interval (CI) 6.4-14.2 %]. CI-AKI was associated with 30-day unfavorable outcome before (45.8 % vs. 19.7 %, P = 0.007) and after [odds ratio (OR) 3.6; 95 % CI 1.4-9.5] adjustment for confounders. No independent risk factors of CI-AKI were identified. Conclusions: CI-AKI incidence was as high as 10.3 % following intravenous contrast media administration in the pediatric setting. As reported among adults, CI-AKI was associated with unfavorable outcome after adjustment for confounders. Although additional studies are needed in the pediatric setting, our data suggest that physicians should maintain a high degree of suspicion toward this complication among pediatric patients. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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