Cell- and Gene-Based Therapeutics for Periodontal Regeneration.

Autor: Abbayya, Keshava, Zope, Sameer Anil, Naduwinmani, Sanjay, Pisal, Apurva, Puthanakar, Nagraj
Předmět:
Zdroj: International Journal of Preventive Medicine; 2015, Vol. 6 Issue 1, p1-5, 5p
Abstrakt: Periodontitis is a disease of the periodontium, characterized by loss of connective tissue attachment and supporting the alveolar bone. Therefore, to regenerate these lost tissues of the periodontium researchers have included a variety of surgical procedures including grafting materials growth factors and the use of barrier membranes, ultimately resulting into regeneration that is biologically possible but clinically unpredictable. Recently a newer approach of delivering DNA plasmids as therapeutic agents is gaining special attention and is called gene delivery method. Gene therapy being considered a novel approach have a potential to channel their signals in a very systematic and controlled manner thereby providing encoded proteins at all stages of tissue regeneration. The aim of this review was to enlighten a view on the application involving gene delivery and tissue engineering in periodontal regeneration. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index