Prognostic value of immunohistochemical expression profile of epidermal growth factor receptor in urothelial bladder cancer.

Autor:	Arfaoui, Amira Toumi, Mejri, S., Belhaj, R., Karkni, W., Chebil, M., Rammeh, S.
Předmět:	EPIDERMAL growth factor receptors BLADDER cancer diagnosis IMMUNOHISTOCHEMISTRY STATISTICAL correlation GENE expression BIOMARKERS
Zdroj:	Journal of Immunoassay & Immunochemistry; 2016, Vol. 37 Issue 4, p359-367, 9p
Abstrakt:	We studied epidermal growth factor receptor (EGFR) expression profile in urothelial bladder carcinoma (UBC) which is a complex and heterogeneous disease with a large spectrum of histological aspects and deadly potential. Using immunohisto-chemistry (IHC), all GI tumors and pTa cases showed a low expression profile of EGFR. However, we note that when the stage of disease is advanced, tumors over-express EGFR. Indeed, 5% and 25% of GII and GIII tumors over-expressed EGFR, respectively. Further, 0% of pTa, 9,5% of pT1, 15% of pT2, 50% of pT3, and 90% of pT4 tumors were shown to be high EGFR expression (HEE). Moreover, we found a statistically significant correlation between the EGFR over-expression and grade and stage (P < 0.05). Thus, EGFR over-expression could be a potential prognostic marker to predict poor outcome in Tunisian patients with UBC. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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