| Autor: |
Jadhav, Ajit C., Shahi, Sadhana R., Tadvi, Imran, Borde, Santosh D. |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutical Research & Allied Sciences; 2016, Vol. 5 Issue 1, p58-64, 7p |
| Abstrakt: |
A simple, rapid, precise, and economical spectrophotometric method has been developed for the quantitative estimation of Losartan Potassium in Bulk and pharmaceutical formulation. The simple, precise, economical and rapid method was developed and validated for the estimation of Losartan Potassium using Distilled Water as a solvent. The stock solution of Losartan Potassium was prepared and subsequent suitable dilution was prepared in Distilled water to obtained standard curve. The standard solution of Losartan Potassium shows absorption maxima at 205nm. The drug obeyed beer lambert's law in the concentration range of 2-10µg/ mL with regression 0.9997 at 205 nm. The overall % recovery was found to be 99.99% which reflects that the method is free from interference of the impurities and other additives used in formulation. The low value of % RSD was indicative of accuracy and reproducibility of the method. The %RSD for interday and intraday precision was found to be 0.5421 and 0.7747, respectively which is <2% hence proved that method is precise. The results of analysis have been validated as per ICH guidelines. The developed method can be adopted in routine analysis of Losartan Potassium in tablet dosage form as well bulk dosage form. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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