| Autor: |
Zita, Cestmír, Overvad, Kim, Mortensen, Svend Aage, Sindberg, Christian Dan, Moesgaard, Sven, Hunter, Douglas A. |
| Předmět: |
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| Zdroj: |
Biofactors; 2003, Vol. 18 Issue 1-4, p185-193, 9p, 4 Charts, 1 Graph |
| Abstrakt: |
Serum coenzyme Q_{10} (Q_{10}) concentrations were evaluated in healthy male volunteers supplemented with 30 mg or 100 mg Q_{10} or placebo as a single daily dose for two months in a randomised, double-blind, placebo-controlled study. Median baseline serum Q_{10}concentration in 99 men was 1.26 mg/l (10%, 90% fractiles: 0.82, 1.83). Baseline serum Q_{10} concentration did not depend on age, while borderline significant positive associations were found for body weight and smoking 1–10 cigarettes/d. Supplementation with 30 mg or 100 mg Q_{10} resulted in median increases in serum Q_{10} concentration of 0.55 mg/l and 1.36 mg/l, respectively, compared with a median decrease of 0.23 mg/l with placebo. The changes in the Q_{10} groups were significantly different from that in the placebo group, and the increase in the 100 mg Q_{10} group was significantly greater than that in the 30~mg Q_{10} group. The change in serum Q_{10}concentration in the Q_{10} groups did not depend on baseline serum _{10} concentration, age, or body weight. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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