| Autor: |
Jao, Edwin, Bogen, Stephane, Saksena, Anil K., Girijavallabhan, Viyyoor |
| Předmět: |
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| Zdroj: |
Synthesis; Dec2003, Vol. 2003 Issue 17, p2643-2646, 4p |
| Abstrakt: |
Lactam 6 derived from (S)-pyroglutaminol was converted to a conformationally restricted congener of nonproteinogenic 3hydroxy-4-methylproline. Preparation of precursor 5b was achieved via a diastereoselective epoxidation followed by a regioselective opening of the oxirane ring. Iodine-mediated cyclization was used to assemble the ether moiety of 2. Key words: nonpeptidic; conformationally rigid; prolinol. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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