Radioresistance of Brain Tumors.
Autor: | Kelley, Kevin, Knisely, Jonathan, Symons, Marc, Ruggieri, Rosamaria |
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Předmět: |
RADIATION-sensitizing agents
APOPTOSIS BRAIN BRAIN tumors CELLULAR signal transduction DNA GENE expression GROWTH factors RADIATION RADIOTHERAPY STEM cells TRANSCRIPTION factors TRANSFERASES TUMORS in children DNA-binding proteins GENETIC markers TREATMENT effectiveness SIGNAL peptides CHEMICAL inhibitors THERAPEUTICS |
Zdroj: | Cancers; Apr2016, Vol. 8 Issue 4, p42, 28p |
Abstrakt: | Radiation therapy (RT) is frequently used as part of the standard of care treatment of the majority of brain tumors. The efficacy of RT is limited by radioresistance and by normal tissue radiation tolerance. This is highlighted in pediatric brain tumors where the use of radiation is limited by the excessive toxicity to the developing brain. For these reasons, radiosensitization of tumor cells would be beneficial. In this review, we focus on radioresistance mechanisms intrinsic to tumor cells. We also evaluate existing approaches to induce radiosensitization and explore future avenues of investigation. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
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