Absence of a reservoir of Epstein-Barr virus (EBV) in normal tongue epithelium.

Autor: D. A. Miller, H. F., Heard, P. L., Cagle, M. P., DiMaio, D., Ench, Y., Morrison, D. G., Eagan, P. A., Gulley, M. L., Jenson, H. B., Moyer, M. P.
Předmět:
Zdroj: Journal of Oral Pathology & Medicine; Apr1994, Vol. 23 Issue 4, p156-160, 5p
Abstrakt: We examined human tongue epithelium and serum samples at autopsy for evidence of latent Epstein-Barr virus (EBV) infection. Although clinical serology revealed anti-EBV antibodies in most sera indicating past EBV infection, we found no Epstein-Barr nuclear antigen (EBNA)-coding sequences in tongue tissue by polymerase chain reaction (PCR), or Epstein-Barr-encoded RNA (EBER1) by in situ hybridization. Tongue epithelium does not appear to be a natural reservoir for latent EBV in immunocompetent hosts. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index