Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study.

Autor:	Terra Junior, Orlando Nascimento, Maldonado, Gabriel de Carvalho, Alfradique, Guilherme Rohem, Lisboa, Vinicius da Cunha, Arnóbio, Adriano, de Lima, Dirce Bonfim, Diamond, Hilda Rachel, de Souza, Maria Helena Faria Ornellas, Arnóbio, Adriano
Předmět:	CELL-mediated cytotoxicity HIV-positive persons CANCER patients KILLER cells BLOOD testing FLOW cytometry AIDS CELL receptors COMPARATIVE studies HIV infections RESEARCH methodology MEDICAL cooperation RESEARCH TUMORS EVALUATION research CROSS-sectional method CASE-control method
Zdroj:	Scientific World Journal; 6/13/2016, p1-11, 11p
Abstrakt:	The NCR receptors play a fundamental role in the cytotoxicity mediated by NK cells against tumor cells. In the current study, we investigated possible HIV/AIDS-related changes in the expression of the NCR receptors comparing healthy donors, HIV/AIDS patients, and HIV/AIDS patients with cancer (HIV/AIDSWC). The NCRs were quantified in NK cells (NK(dim) and NK(bright)) and T lymphocytes from peripheral blood samples by flow cytometry. We found a significant decrease in the frequency of NK cells expressing NKp46 in HIV/AIDS group (p = 0.0012). There was a decrease in the frequency of NK cells expressing NKp46 in the HIV/AIDSWC group; however, this was not statistically significant. We found a significant decrease in the frequency of NK cells expressing NKp30 in the HIV/AIDS group (p = 0.0144). There was a decrease in the frequency of NK cells expressing NKp30 and in the HIV/AIDSWC group, but this was not statistically significant. There were no changes in the distribution of NK cells and their subtypes in both groups. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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