| Autor: |
Jiang, Zhi‐Yong, Zhu, Le‐Yu, Zhou, Jun, Hu, Qiu‐Fen, Yang, Guang‐Yu, Huang, Xiang‐Zhong, Liu, Wen‐Xing, Gao, Lu, Li, Gan‐Peng, Xia, Fu‐Ting |
| Zdroj: |
Helvetica Chimica Acta; Jun2016, Vol. 99 Issue 6, p452-456, 5p |
| Abstrakt: |
A novel terpenoid, named perovskiaol ( 1), was isolated from the cultured Perovskia atriplicifolia. Its structure was elucidated by comprehensive spectroscopic analysis as well as by quantum chemical computation of electronic circular dichroism spectra. Perovskiaol ( 1) was a novel C22 terpenoid containing a unique D-ring simultaneously fused with rings A, B, and C, and encountered in nature for the first time. Cytotoxic bioassay suggested perovskiaol ( 1) possessed significant cytotoxic activity inhibiting NB4, A549, and HepG 2 cell lines with IC50 values of 2.35, 1.47, and 0.81 μ m, respectively. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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