Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: a double-blind randomized control trial.

Autor: Hsin-Fu Lin, Kang Tung, Chun-Chung Chou, Ching-Che Lin, Jaung-Geng Lin, Hirofumi Tanaka
Předmět:
THERAPEUTIC use of ginseng
LIPID analysis
PHYSIOLOGICAL adaptation
ANALYSIS of variance
ANTHROPOMETRY
BIOMARKERS
BLOOD flow measurement
VASODILATION
CARDIOPULMONARY system
STATISTICAL correlation
CREATINE kinase
DIETARY supplements
ENZYME-linked immunosorbent assay
EXERCISE
EXERCISE physiology
EXERCISE tests
GINSENG
HEMODYNAMICS
HERBAL medicine
HIGH performance liquid chromatography
INFLAMMATION
INTERLEUKINS
RANGE of motion of joints
VASCULAR resistance
CHINESE medicine
MYALGIA
RESEARCH funding
RUNNING
STATISTICAL sampling
STATISTICS
TUMOR necrosis factors
ULTRASONIC imaging
UNIVERSITIES & colleges
STATISTICAL power analysis
DATA analysis
QUANTITATIVE research
PAIN measurement
RANDOMIZED controlled trials
VISUAL analog scale
REPEATED measures design
BLIND experiment
MEASUREMENT of angles (Geometry)
DATA analysis software
SKELETAL muscle
DESCRIPTIVE statistics
DRUG administration
DRUG dosage
Zdroj: BMC Complementary & Alternative Medicine; 6/6/2016, Vol. 16, p1-10, 10p, 1 Diagram, 5 Charts, 5 Graphs
Abstrakt: Background: Muscle damage induced by unaccustomed or eccentric exercise results in delayed onset vascular stiffening. We tested the hypothesis that a 7-day supplementation of and prior to panax ginseng salvia miltiorrhiza an acute eccentric exercise could attenuate arterial stiffening. Methods: By using a double-blind study placebo-controlled randomized design, subjects were randomly assigned to either the Chinese herb (N = 12) or the placebo group (N = 11) and performed a downhill running (eccentric exercise) trial and a control (seated rest) trial. Results: Muscle soreness increased 1-2 days after exercise similarly in both groups, whereas the herb group demonstrated a faster recovery on active range of motion. Plasma creatine kinase concentration increased significantly at 24 h in both groups but the magnitude of increase was attenuated in the herb group. Arterial stiffness as measured by carotid-femoral pulse wave velocity increased significantly at 24 h in the placebo group but such increase was absent in the herb group. Flow-mediated dilation did not change in either group. Plasma concentrations of CRP and IL-6 increased in the placebo group but no such increases were observed in the herb group. Changes in arterial stiffness induced by eccentric exercise were associated with the corresponding changes in IL-6 (r =0.4 6, <0.05). Conclusions: A short-term Chinese herb supplementation of and ameliorated the panax ginseng salvia miltiorrhiza delayed onset vascular stiffening induced by acute downhill running exercise. Trial registration: ClinicalTrials.gov: NCT02007304. Registered Dec. 5, 2013) [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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