Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: a double-blind randomized control trial.
Autor: | Hsin-Fu Lin, Kang Tung, Chun-Chung Chou, Ching-Che Lin, Jaung-Geng Lin, Hirofumi Tanaka |
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Předmět: |
THERAPEUTIC use of ginseng
LIPID analysis PHYSIOLOGICAL adaptation ANALYSIS of variance ANTHROPOMETRY BIOMARKERS BLOOD flow measurement VASODILATION CARDIOPULMONARY system STATISTICAL correlation CREATINE kinase DIETARY supplements ENZYME-linked immunosorbent assay EXERCISE EXERCISE physiology EXERCISE tests GINSENG HEMODYNAMICS HERBAL medicine HIGH performance liquid chromatography INFLAMMATION INTERLEUKINS RANGE of motion of joints VASCULAR resistance CHINESE medicine MYALGIA RESEARCH funding RUNNING STATISTICAL sampling STATISTICS TUMOR necrosis factors ULTRASONIC imaging UNIVERSITIES & colleges STATISTICAL power analysis DATA analysis QUANTITATIVE research PAIN measurement RANDOMIZED controlled trials VISUAL analog scale REPEATED measures design BLIND experiment MEASUREMENT of angles (Geometry) DATA analysis software SKELETAL muscle DESCRIPTIVE statistics DRUG administration DRUG dosage |
Zdroj: | BMC Complementary & Alternative Medicine; 6/6/2016, Vol. 16, p1-10, 10p, 1 Diagram, 5 Charts, 5 Graphs |
Abstrakt: | Background: Muscle damage induced by unaccustomed or eccentric exercise results in delayed onset vascular stiffening. We tested the hypothesis that a 7-day supplementation of and prior to panax ginseng salvia miltiorrhiza an acute eccentric exercise could attenuate arterial stiffening. Methods: By using a double-blind study placebo-controlled randomized design, subjects were randomly assigned to either the Chinese herb (N = 12) or the placebo group (N = 11) and performed a downhill running (eccentric exercise) trial and a control (seated rest) trial. Results: Muscle soreness increased 1-2 days after exercise similarly in both groups, whereas the herb group demonstrated a faster recovery on active range of motion. Plasma creatine kinase concentration increased significantly at 24 h in both groups but the magnitude of increase was attenuated in the herb group. Arterial stiffness as measured by carotid-femoral pulse wave velocity increased significantly at 24 h in the placebo group but such increase was absent in the herb group. Flow-mediated dilation did not change in either group. Plasma concentrations of CRP and IL-6 increased in the placebo group but no such increases were observed in the herb group. Changes in arterial stiffness induced by eccentric exercise were associated with the corresponding changes in IL-6 (r =0.4 6, <0.05). Conclusions: A short-term Chinese herb supplementation of and ameliorated the panax ginseng salvia miltiorrhiza delayed onset vascular stiffening induced by acute downhill running exercise. Trial registration: ClinicalTrials.gov: NCT02007304. Registered Dec. 5, 2013) [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
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