| Autor: |
S. M., Satyam, K. L., Bairy, S., Musharaf, D., Fernandes, P. Y., Prakash |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutical, Chemical & Biological Sciences; Jul-Sep2015, Vol. 5 Issue 3, p683-687, 5p |
| Abstrakt: |
Zincoderm GM cream is a fixed dose combination of clobetasol, gentamicin, miconazole and zinc. Studies have been done for efficacy of each component like clobetasol, gentamicin and miconazole but as fixed dose combination including Zinc has not been reported yet. Hence a study was planned to assess the efficacy of Zincoderm GM cream in experimental Tinea pedis in animal models. In the experiment a total of 24 Wistar rats (male, pathogen free, 6-8 weeks old) were used. The rats were divided into 4 groups of 6 rats each. 25-30 mg of test drugs (Zincoderm GM cream with or without Zinc) was applied on infected paws from 10th day of post-infection. Fungal infection was assessed by clinical response scoring system and fungal culture examination. Clinical response (p<0.003) as well as fungal scores (p<0.001) was significantly lower in Tinea pedis induced rats treated with Zincoderm GM cream with Zinc when compared to Tinea pedis induced control (untreated) rats. There was no significant difference in clinical response scores (P<0.0264) between Zincoderm GM with zinc and Zincoderm GM without zinc treatment groups. However, there was significantly lower fungal score(P<0.019) in Tinea pedis induced rats treated with Zincoderm GM cream with Zinc in comparison with Tinea pedis induced rats treated with Zincoderm GM cream without Zinc. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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