| Autor: |
Rao, Alla Narayana, Bhargav, Y., Krishna, B. Sai, Teja, M. Prasanna, Bose, M. S. C. |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutical, Chemical & Biological Sciences; Jan-Mar2015, Vol. 5 Issue 1, p98-105, 8p |
| Abstrakt: |
Plasma glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP Binding Cassette (ABC) super family that functions specifically as carrier mediated primary active efflux transporter. It is widely distributed throughout the body and has a diverse range of substrates. Several vital therapeutic agents are substrates to P-gp and their bioavailability is lowered or a resistance is induced because of protein efflux. Hence P-gp inhibitors were explored for overcoming multidrug resistance and poor bioavailability problems of the therapeutic P-gp substrates. This review represents a brief discussion on P-gp mediated drug transport and how it hinders the success of various therapies. Its main focus is on various strategies used to improve the drug delivery and targeting. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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