| Abstrakt: |
Objectives: The aim of the present study was comparing the effects of dried Saffron with of diazepam in reducing anxiety before herniorrhaphy surgery. Materials and Methods: In this double-blind clinical trial, 102 patients aged between 5-18 years, were studied for ten months in 15th Khordad Hospital of Gonabad during 2011-2012. Samples were chosen randomly based on the goal of our study. Then, according to the table of random numbers, they were divided into intervention and control groups. For the intervention group, 25 mg of dried saffron, and 5mg of diazepam for the control group was prescribed three hours before herniorrhaphy surgery. Patients filled the Spielberger anxiety questionnaire before consuming the drug and immediately after entering the operating room. Data were analysed using Spearman statistical test, Pearson correlation coefficient, and T-student test. Results: The amount of hidden anxiety decreased in the intervention group after consuming the drug (from 34.51 ±7.4 to 34.72± 7.45), and it increased in the control group (from 34.51± 10.74 to 69.97 ± 38.8) (p<0.05). Paired t-test showed a significant statistical difference in diazepam group before and after the intervention (p=0.007), also, in the Saffron group before and after intervention (p=0.046). In addition, there was a significant statistical difference in both Diazepam and Saffron groups after the intervention (p=0.019), that is, anxiety in the Saffron group was less than the diazepam group. Conclusion: According to the results of our study, Saffron dried extract can be used as an effective prodrug in decreasing anxiety, especially before surgery. [ABSTRACT FROM AUTHOR] |
