| Autor: |
Velarde-Félix, Jesús Salvador, Cázarez-Salazar, Silvestre Guadalupe, Díaz-Camacho, Sylvia Páz, Osuna-Ramírez, Ignacio, Ochoa-Ramírez, Luis antonio, Sánchez-Zazueta, Jorge Guillermo, Ramírez, Martín |
| Předmět: |
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| Zdroj: |
Intervirology; May2016, Vol. 58 Issue 6, p357-362, 6p |
| Abstrakt: |
Objective: To evaluate the association of the stromal cellderived factor-1 (SDF1)-3 ' A polymorphism to HIV-1 infection, CD4+ T-lymphocyte counts, and viral load levels in a northwestern Mexican population. Methods: We investigated allele and genotype frequencies of the SDF1-3 ' A polymorphism in 634 mestizo individuals from Northwest Mexico (204 HIV-1 infected persons, 256 uninfected blood donors, and 174 uninfected female sex workers) by the PCRRFLP method and compared them using a χ 2 test. We also searched for correlations between the polymorphism and CD4+ T lymphocyte and viral load counts. Results: No differences were observed in the frequencies of alleles and genotypes between patients and controls. However, in female pa- tients we found a significantly increased prevalence of both the A allele and GA heterozygous genotype compared to male patients, female blood donors, and female sex workers. Conclusion: Here we describe the association of the SDF1- 3 ' A polymorphism with HIV-1 infection only in women, but not to CD4+ T-lymphocyte categories, viral load levels in patients with HIV-1/AIDS, or to exposure levels in female sex workers. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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