| Autor: |
Gysbrechts, Barbara, Wang, Ling, Trong, Nghia Nguyen Do, Cabral, Henrique, Navratilova, Zaneta, Battaglia, Francesco, Saeys, Wouter, Bartic, Carmen |
| Zdroj: |
Journal of Biophotonics; Jun2016, Vol. 9 Issue 6, p576-585, 10p |
| Abstrakt: |
Optical brain stimulation gained a lot of attention in neuroscience due to its superior cell-type specificity. In the design of illumination strategies, predicting the light propagation in a specific tissue is essential and requires knowledge of the optical properties of that tissue. We present the estimated absorption and reduced scattering in rodent brain tissue using non-destructive contact spatially resolved spectroscopy (cSRS). The obtained absorption and scattering in the cortex, hippocampus and striatum are similar, but lower than in the thalamus, leading to a less deep but broader light penetration profile in the thalamus. Next, the light distribution was investigated for different stimulation protocols relevant for fiber-optic based optogenetic experiments, using Monte Carlo simulation. A protocol specific analysis is proposed to evaluate the potential of thermally induced side effects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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