| Autor: |
Cidade Torres, Fernando, Oliveira de Azambuja, Gabriel, Gonçalves, Itamar Luís, Arraché Gonçalves, Guilherme, Lino von Poser, Gilsane, Fábio Kawano, Daniel, Eifler-Lima, Vera Lucia |
| Předmět: |
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| Zdroj: |
Molbank; Jun2016, Vol. 2016 Issue 2, pm894, 3p |
| Abstrakt: |
Nature often produces compounds with a high degree of symmetry to reduce structural information and complexity. Synthesis of identical twin drugs, through the linkage of two identical pharmacophoric entities, is a classical strategy to produce more potent and/or selective drugs. Herein, two units of the privileged core of the coumarin hymecromone were linked together using "click chemistry". Synthesis of 1-[2-(4-Methyl-7-coumarinyloxy)ethyl]-4-(5-{1-[2-(4-methyl-7-coumarinyloxy)ethyl]-1H-1,2,3-triazol-4-yl}pentyl)-1H-1,2,3-triazole was achieved by coupling of two identical units of an azido coumarin with a symmetrical alkine using copper(I)-catalyzed alkyne-azide cycloaddition reaction, in good yields and with complete regioselectivity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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