| Autor: |
Al-Masoudi, Najim A., March, Yossra A., Al-Ameri, Jenan J., Ali, Dawood S., Pannecouque, Christophe |
| Předmět: |
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| Zdroj: |
Chemistry & Biology Interface; Mar/Apr2016, Vol. 6 Issue 2, p69-73, 5p |
| Abstrakt: |
A series of substituted nitrosopyrimidineanalogues were evaluated in vitro against the replication of HIV-1 and HIV-2 in MT-4 cells using MTT method. 4,6-Diamino-5-nitrosopyrimidine (23) showed an IC50 values of > 0.44 μM with SI <1. This means that 23was cytotoxic to MT-4 cells at a CC50 value of > 0.44 μM.In addition, 6-amino-5-nitroso-2-phenylpyrimidine-4-one (22) and phenyl (2,6-diamino-5-nitrosopyrimidin-4-yl) benzoate (36) were cytotoxic to MT-4 cells at concentration of 6.92 and 6.85μM, respectively. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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