| Autor: |
Weyand, Eric H., Modi, Nehal, Parimoo, Bhama, Mauro, David M., Craig, David R. |
| Předmět: |
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| Zdroj: |
Polycyclic Aromatic Compounds; Jul-Oct2002, Vol. 22 Issue 3/4, p911-921, 11p, 1 Black and White Photograph, 2 Charts, 3 Graphs |
| Abstrakt: |
Previous studies have demonstrated that mouse lung is a target organ for the tumorigenic and genotoxic effects of coal tar. The present study evaluated PAH:DNA adduct formation in lung, liver, forestomach, and mammary gland of female CD rats fed various types of coal tar-contaminated diets. Coal tar-contaminated soil, an organic extract of contaminated soil, neat coal tar, and diets containing only B[ a ]P were evaluated. Ingestion of coal tar diets resulted in detectable levels of DNA adducts in lung and forestomach tissue. These adducts were primarily derived from benzo[ c ]fluorene and B[ a ]P. The adduct derived from benzo[ c ]fluorene was the most predominant. No adducts were detected in liver and mammary gland under the conditions employed in this study. The formation of a benzo[ c ]fluorene-derived DNA adduct in rat lung following coal tar exposure is consistent with previous studies performed with mice. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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