Pd-Catalyzed sequential β-C(sp3)–H arylation and intramolecular amination of δ-C(sp2)–H bonds for synthesis of quinolinones via an N,O-bidentate directing group.

Autor:	Guan, Mingyu, Pang, Yubo, Zhang, Jingyu, Zhao, Yingsheng
Předmět:	PALLADIUM compounds ARYLATION AMINATION CATALYSIS CARBON-hydrogen bonds QUINOLONE antibacterial agents synthesis
Zdroj:	Chemical Communications; 5/28/2016, Vol. 52 Issue 43, p7043-7046, 4p
Abstrakt:	The pharmacological importance of 2-quinolinone derivatives is well known. Herein, we developed an effective protocol for the synthesis of 2-quinolinone derivatives by palladium-catalyzed sequential β-C(sp3)–H arylation and selective intramolecular C(sp2)–H/N–H amination starting with aryl iodides and carboxylic acids. A novel directing group, glycine dimethylamide, was used in the synthesis. We synthesized various quinolinone derivatives, including 5-substituted quinolinones, which are difficult to obtain using the traditional pathway. The directing group could be easily removed and could be readily transformed into other useful functional groups. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu