| Abstrakt: |
In a group of healthy, non-vegetarian females currently being treated for diffuse androgen-dependent alopecia with 50 or 100 mg of oral cyproterone acetate for 11 days and 30 or 40 μg of ethinyl oestradiol for 20 days of the menstrual cycle, significant decreases in mean serum vitamin B[SUB12] (P < 0.0001), haemoglobin (P<0.003) and haematocrit (P<(1.004) values, were observed after 6 months. Serum folic acid, red-cell folate and mean cell volume remained unchanged within the normal range during this time. All patients responded to oral cyanocobalamin, or intramuscular injections of hydroxocobalamin. In patients with baseline serum vitamin B[SUB12] levels below 350 ng/I, we would suggest prophylactic cyanocohalamin concurrent with cyproterone-acetate ethinyloestradiol (CPA EE[SUB2]) therapy. Studies involving other dose regimens of CPA EE[SUB2] (Dianette™) or cyproterone acetate alone (Androcur™, Cyprostat™, may require evaluation of the vitamin B[SUB12] status if treatment is to be given for periods of longer than 3 months. [ABSTRACT FROM AUTHOR] |
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