Comparison of Calipers for Matching on the Disease Risk Score.
| Autor: | Connolly, John G., Gagne, Joshua J. |
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| Předmět: |
ALZHEIMER'S disease diagnosis
DIAGNOSIS of diabetes DISEASE risk factors GASTROINTESTINAL hemorrhage treatment HEART disease risk factors RISK factors of fractures CATARACT COMBINATION drug therapy CONFIDENCE intervals DATABASES DEMOGRAPHY MENTAL depression CLINICAL drug trials CROHN'S disease EPIDEMIOLOGY EPIDEMIOLOGICAL research HOSPITAL care LONGITUDINAL method OBSTRUCTIVE lung diseases MEDICAID MEDICAL care NONSTEROIDAL anti-inflammatory agents NOSOLOGY PATIENTS PHARMACOLOGY RESEARCH funding TUMORS WEIGHTS & measures COMORBIDITY LOGISTIC regression analysis CYCLOOXYGENASE 2 RALOXIFENE DATA analysis EQUIPMENT & supplies EZETIMIBE SIMVASTATIN CONFOUNDING variables ODDS ratio |
| Zdroj: | American Journal of Epidemiology; 5/15/2016, Vol. 183 Issue 10, p937-948, 12p |
| Abstrakt: | Previous studies have compared calipers for propensity score (PS) matching, but none have considered calipers for matching on the disease risk score (DRS). We used Medicare claims data to perform 3 cohort studies of medication initiators: a study of raloxifene versus alendronate in 1 -year nonvertebral fracture risk, a study of cyclooxygenase 2 inhibitors versus nonselective nonsteroidal antiinflammatory medications in 6-month gastrointestinal bleeding, and a study of simvastatin + ezetimibe versus simvastatin alone in 6-month cardiovascular outcomes. The study periods for each cohort were 1998 through 2005,1999 through 2002, and 2004 through 2005, respectively. In each cohort, we calculated 1) a DRS, 2) a prognostic PS which included the DRS as the independent variable in a PS model, and 3) the PS for each patient. We then nearest-neighbor matched on each score in a variable ratio and a fixed ratio within 8 calipers based on the standard deviation of the logit and the natural score scale. When variable ratio matching on the DRS, a caliper of 0.05 on the natural scale performed poorly when the outcome was rare. The prognostic PS did not appear to offer any consistent practical benefits over matching on the DRS directly. In general, logit-based calipers or calipers smaller than 0.05 on the natural scale performed well when DRS matching in all examples. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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