| Autor: |
Okunola, T. O., Ajenifuja, K. O., Ogunniyi, S. O., Aboderin, A. O. |
| Předmět: |
|
| Zdroj: |
International Journal of Medicine & Biomedical Research; Jan-Apr2016, Vol. 5 Issue 1, p35-42, 8p |
| Abstrakt: |
Background: Chlamydia infection in pregnancy is associated with perinatal and neonatal complications like prelabour rupture of membranes, preterm birth, low birth weight, neonatal inclusion conjunctivitis and neonatal pneumonia. Aim: The aim of the study was to compare the efficacy and tolerability of erythromycin with amoxicillin in the management of Chlamydia trachomatis infection in pregnant women. Methods: Two hundred and twenty pregnant women that were positive to the rapid Chlamydia antigen test were randomized to receive either amoxicillin or erythromycin for one week at the antenatal clinics of Obafemi Awolowo University Teaching Hospitals Complex, lle-lfe. Their partners were treated with doxycycline for 1 week and barrier contraception was used by the couples during the treatment. The subjects were re-screened four weeks after enrolment. Data was analyzed with SPSS version 20 and P-value <0.05 was taken as statistically significant. Results: The microbiological clearance rates were 93.2% and 97% for Amoxicillin and Erythromycin respectively. The difference was however not significant (Exact 1.60, p=0.33). The relative risk was 0.96; 95% CI 0.9-1.0. There was also no statistically significant difference in occurrence of side effects. (χ²=1.38; P = 0.28) and drug discontinuation rates. Conclusion: Amoxicillin was comparable to erythromycin for the treatment of antenatal Chlamydia trachomatis infection. The drug discontinuation rates and occurrence of side effects were similar. Therefore, amoxicillin is an effective alternative for treatment of antenatal Chlamydial infection when there is significant side effect with the use of erythromycin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
