Combination of inverse electron-demand Diels–Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations.

Autor:	Hörner, S., Uth, C., Avrutina, O., Frauendorf, H., Wiessler, M., Kolmar, H.
Předmět:	DIELS-Alder reaction COUPLING reactions (Chemistry) NANOPARTICLE synthesis OXIMES SILICONES LIGATION reactions BIOCONJUGATES
Zdroj:	Chemical Communications; 7/14/2015, Vol. 51 Issue 55, p11130-11133, 4p
Abstrakt:	A modular approach combining inverse electron-demand Diels–Alder coupling (DARinv) and oxime ligation expands the toolbox of bioorthogonal peptide chemistry. Applicability of versatile site-specific bifunctional building blocks is demonstrated by generation of defined conjugates comprising linear, cystine-bridged and multi-disulfide functional peptides as well as their conjugation with hybrid silsesquioxane nanoparticles. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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