| Autor: |
Ferraro, Giarita, Massai, Lara, Messori, Luigi, Merlino, Antonello |
| Předmět: |
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| Zdroj: |
Chemical Communications; 6/11/2015, Vol. 51 Issue 46, p9436-9439, 4p |
| Abstrakt: |
The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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