| Autor: |
Jebali, Khaoula, Planchat, Aurélien, Amri, Hassen, Mathé-Allainmat, Monique, Lebreton, Jacques |
| Předmět: |
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| Zdroj: |
Synthesis; 2016, Vol. 48 Issue 10, p1502-1517, 16p |
| Abstrakt: |
A Brønsted acid promoted intramolecular Friedel-Crafts cyclization of β-benzoyl- and β-acetylpyrrol-2(5H)-one derivatives tethered via nitrogen to an electron-rich arene nucleus is developed. Using this efficient methodology, various pyrrolo[2,1-α]isoquinoline and pyrrolo[2,1-a]benzazepine derivatives are prepared in a two-step sequence starting from readily available ethyl (Z)-3-bromomethyl-4-oxo-4-phenylbut-2-enoate or ethyl (Z)-3-bromomethyl-4-oxopent-2-enoate. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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