Relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetic patients (JDDM38).

Autor: Kanatsuka, Azuma, Sato, Yasunori, Kawai, Koichi, Hirao, Koichi, Kobayashi, Masashi, Kashiwagi, Atsunori, Abe, Nobuyuki, Arai, Keiko, Fujiya, Hiroshi, Fukumoto, Yoshihide, Dake, Fumihiko, Iizumi, Tomohiro, Ito, Masaaki, Iwasaki, Koichi, Kanamori, Akira, Kato, Sumio, Kato, Masakazu, Kawara, Akira, Kimura, Kenichi, Chikamori, Kazumasa
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Zdroj: Journal of Diabetes Investigation; May2016, Vol. 7 Issue 3, p386-395, 10p
Abstrakt: Aims/Introduction We carried out an observational cohort study to examine the relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetics. Materials and Methods We analyzed the CoDiC® database of the Japan Diabetes Data Management Study Group across 67 institutions in Japan. In a total of 3,698 drug-naïve patients who were initiated with metformin, dipeptidyl peptidase-4 inhibitor (DPP-4i) or sulfonylurea ( SU) from 2007 to 2012, we evaluated body mass index ( BMI) and hemoglobin A1c (HbA1c). The patients were stratified according to their clinical features, and matched using a propensity score to adjust for baseline factors. Results HbA1c was reduced with all drugs, with the largest effect elicited by DPP-4i and the smallest by SU ( P = 0.00). HbA1c increased with SU after 6 months in the patients stratified by an age-of-onset of <50 years ( P = 0.00). BMI increased with SU in the patients stratified by a BMI of <25 ( P = 0.00), and decreased with metformin in the patients with a BMI >25 ( P = 0.00). The reduction in HbA1c was larger in patients with HbA1c of ≥8%, compared with that in patients with HbA1c of <8% ( P = 0.00). HbA1c during the study period was higher in patients who were added to or swapped with other drug(s), than in patients continued on the original drug ( P = 0.00). Conclusions The effect on bodyweight and glycemic control differed among metformin, DPP-4i and SU, and the difference was associated with clinical features. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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