| Autor: |
Bhoite, Leena T., Saranath, Dhananjaya, Nair, Rama, Deo, Madhav G., Sanghavi, Vikram, Mehta, Ashok, Bhoite, L T, Saranath, D, Nair, R, Deo, M G, Sanghavi, V, Mehta, A |
| Předmět: |
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| Zdroj: |
Journal of Oral Pathology & Medicine; Aug1993, Vol. 22 Issue 7, p298-302, 5p |
| Abstrakt: |
Restriction fragment length polymorphism (RFLP) of the human H-ras-1 gene has been indicated as a marker for detection of individuals at high risk of cancer. We have investigated the association of RFLP at the H-ras-1 locus and susceptibility to oral cancer by Southern hybridization analysis in 77 primary oral tumors and 99 healthy donors. The frequency distribution of the BamHI fragments of H-ras-1 revealed homozygous or heterozygous alleles in the two subpopulations. The heterozygous genotype occurred more frequently in the normal subjects (53%) as compared to the cancer patients (36%). Four common alleles-C1 to C4, were noted predominantly in both groups, with rare alleles detected at a lower frequency. The common allele with 7.6 kb BamHI fragment was significantly higher in normals (10%) than in the tumor population (4%) (P < 0.05). However, a similar distribution of rare alleles in both groups indicated that the presence of rare alleles is not indicative of predisposition to oral cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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