Detection of subclinical recurrence or second primary cancer using 18F-FDG PET/CT in patients treated curatively for head and neck squamous cell carcinoma.

Autor: Kikuchi, Masahiro, Shinohara, Shogo, Hino, Megumu, Itoh, Kyo, Tona, Risa, Kishimoto, Ippei, Harada, Hiroyuki, Fujiwara, Keizo, Suehiro, Atsushi, Naito, Yasushi
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Zdroj: Head & Neck; Apr2016 Supplement, Vol. 38, pE511-E518, 8p
Abstrakt: Background The efficacy of posttreatment surveillance 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/CT was evaluated in patients with head and neck squamous cell carcinoma (HNSCC). Methods The subjects were 158 patients with HNSCC who underwent PET/CT after definitive treatment. PET/CT detection of subclinical recurrence or a second primary cancer and the effect of timing of PET/CT scans on survival were analyzed. Results Recurrence or a second primary cancer occurred in 70 patients, and 67% of these cases were detected by PET/CT. Detection rates were 17%, 9%, 5%, and 5% in the first, second, third, and fourth scans at 4, 9, 15, and 21 months, respectively. In multivariate analysis, patients who underwent early first scans had significantly better disease-specific (hazard ratio [HR] = 0.37; p = .031) and overall (HR = 0.45; p = .040) survival compared with those who underwent late first scans. Conclusion Earlier detection of subclinical lesions by surveillance PET/CT within 4 months after treatment may improve survival in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E511-E518, 2016 [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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