| Autor: |
Nicolai, Piero, Schreiber, Alberto, Bolzoni Villaret, Andrea, Lombardi, Davide, Morassi, Laura, Raffetti, Elena, Donato, Francesco, Battaglia, Paolo, Turri–Zanoni, Mario, Bignami, Maurizio, Castelnuovo, Paolo |
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| Zdroj: |
Head & Neck; Apr2016 Supplement, Vol. 38, pE996-E1003, 8p |
| Abstrakt: |
Background The purpose of this study was to assess survival, prognostic factors, and complications in a cohort of patients with intestinal-type adenocarcinoma (ITAC) treated with transnasal endoscopic surgery ± radiotherapy (RT). Methods Patients with ITAC who underwent endoscopic surgery ± RT at 2 tertiary centers were retrospectively reviewed. Overall survival (OS) and event-free survival were calculated, and statistically significant variables were entered in a multivariate Cox regression model. Complications were also analyzed. Results One hundred-sixty-nine patients were included. Major complications occurred in 9.5% of patients. Adjuvant RT was delivered in 58.6% of patients. Five-year OS and event-free survival were 68.9% and 63.6%, respectively. Advanced pT classification, high-grade, and positive surgical margins were independently predictive of poor survival. Conclusion Endoscopic surgery ± RT is a valid treatment option in most cases of ITAC. When compared with series based on external surgery, our results support a definitive paradigm shift in the management of ITAC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E996-E1003, 2016 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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