| Autor: |
Tan, Hui Li, Wong, Yeon Yin, Muniyandy, Saravanan, Hashim, Kamaruddin, Pushpamalar, Janarthanan |
| Předmět: |
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| Zdroj: |
Journal of Applied Polymer Science; 7/20/2016, Vol. 133 Issue 28, pn/a-N.PAG, 13p |
| Abstrakt: |
ABSTRACT Carboxymethyl sag o pulp (CMSP)/carboxymethyl sago starch (CMSS) hydrogel was synthesized by electron beam irradiation. In the series of hydrogels prepared, 40%/20% CMSP/CMSS hydrogel had the highest gel fraction. The swelling capacity of CMSP/CMSS hydrogel was found to be highest in distilled water, followed by pH 11, pH 7.4, and pH 1.2. Scanning Electron Microscope photographs revealed that the drug-loaded hydrogel had a smoother surface than unloaded hydrogel. Fourier Transform Infrared and Differential Scanning Calorimetry analysis showed the absence of interaction between the hydrogels and the drug. All drug-loaded hydrogels had drug encapsulation efficiency between 63% and 69%. CMSP/CMSS hydrogel swelled and allowed the release of drug at pH 7.4. These properties qualify the hydrogel as a potential candidate for controlled drug release at the ocular and colonic regions. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43652. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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