Prevalence of Hyperparathyroidism, Mineral and Bone Disorders in Children with Advanced Chronic Kidney Disease.

Autor: Desoky, Sherif, Farag, Youssef, Safdar, Eatidal, Shalaby, Mohamed, Singh, Ajay, Kari, Jameela, El Desoky, Sherif, Farag, Youssef Mk, Shalaby, Mohamed Ahmed, Singh, Ajay K, Kari, Jameela A, Farag, Youssef M K
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Zdroj: Indian Journal of Pediatrics; May2016, Vol. 83 Issue 5, p420-425, 6p
Abstrakt: Objective: To identify the prevalence and risk factors for secondary hyperparathyroidism in children with advanced stages of chronic kidney disease (CKD).Methods: A retrospective cross-sectional observational study of clinical and laboratory data of pediatric patients with CKD stage 3, 4 was conducted from 2005 through 2013 at a single center in the Kingdom of Saudi Arabia.Results: One hundred nineteen children (60.5 % boys) with mean age of 10.1 ± 5.1 y were included in the study. The mean eGFR (estimated Glomerular Filtration Rate) was 18.3 ± 15.4 ml/min/1.73m(2) and the mean intact parathyroid hormone (iPTH) level was 62.2 ± 89.4 pmol/L. Patients with a high iPTH had lower eGFR than those who were euparathyroid (16 ± 13.4 vs. 29.7 ± 19 ml/min/1.73m(2), respectively; p = 0.006), had lower calcium levels (2.2 ± 0.3 vs. 2.4 ± 0.3 mmol/L; p = 0.03) and a lower bicarbonate level (21.2 ± 4.2 vs. 23.3 ± 3.2 mmol/L; p = 0.04). Three children with hyperparthyrodism (4.9 %) had fractures, 16 (26.2 %) had bone deformities compared to 5 in the euoparathyroid group (p = 0.012). Parathyroid hormone negatively correlated with the patient's eGFR (r = -0.55), serum calcium (r = -0.43), and positively correlated with serum phosphate (r = 0.38).Conclusions: The single most important predictor of hyperparathyroidism in children in the present sample was eGFR. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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