| Autor: |
Marquette, C., Linard, C., Galonnier, M., Van Uye, A., Mathieu, J., Gourmelon, P., Clarençon, D. |
| Předmět: |
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| Zdroj: |
International Journal of Radiation Biology; Oct2003, Vol. 79 Issue 10, p777-785, 9p |
| Abstrakt: |
Purpose : To evaluate the central nervous system neuroimmune and inflammatory responses during the prodromal phase of the acute irradiation syndrome in rat brains after partial-body exposure (head-protected) and to investigate the potential neural signalling pathways from the irradiated periphery to the non-irradiated brain. Material and methods : The study included four groups of rats: one irradiated group and one sham irradiated group, each containing non-vagotomized and vagotomized rats. In vagotomized rat groups, the subdiaphragmatic vagal section surgery was carried out 45 days before the irradiation exposure. The rats were partial-body irradiated with the head shielded with 60 Co γ -rays to a dose of 15 Gy. They were sacrificed 6 h after the end of exposure. The hypothalamus, hippocampus, thalamus and cortex were then collected, and the concentrations of IL-1 β , TNF α and IL-6 in each were measured by ELISA assays. Results : Six hours after irradiation, IL-1 β levels had increased in the hypothalamus, thalamus and hippocampus, and TNF α and IL-6 levels had increased significantly in the hypothalamus. Vagotomy before irradiation prevented these responses. Conclusions : It was concluded that the hypothalamus, hippocampus, thalamus and cortex react rapidly to peripheral irradiation by releasing pro-inflammatory mediators. The results also show that the vagus nerve is one of the major ascending pathways for rapid signalling to the brain with respect to partial body irradiation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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