| Autor: |
Kim, Hee-jae, Song, Wook, Jin, Eun, Kim, Jongkyu, Chun, Yoonseok, An, Eung, Park, Sok |
| Předmět: |
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| Zdroj: |
Neurochemical Research; May2016, Vol. 41 Issue 5, p1035-1041, 7p |
| Abstrakt: |
Physical exercise and vitamins such as ascorbic acid (ASC) have been recognized as an effective strategy in neuroprotection and neurorehabilitatioin. However, there is a need to find an efficient treatment regimen that includes ASC and low-intensity exercise to diminish the risk of overtraining and nutritional treatment by attenuating oxidative stress. In the present study, we investigated the combined effect of low-intensity physical exercise (EX) and ASC on kainic acid (KA)-induced seizure activity and oxidative stress in mice. The mice were randomly assigned into groups as follows: 'KA only' (n = 11), 'ASC + KA' (n = 11), 'Ex + KA' (n = 11), 'ASC + Ex + KA' (n = 11). In the present study, low intensity of swimming training period lasted 8 weeks and consisted of 30-min sessions daily (three times per week) without tail weighting. Although no preventive effect of low-intensity exercise or ASC on KA seizure occurrence was evident, there was a decrease of seizure activity, seizure development (latency to first seizures), and mortality in 'ASC + Ex + KA' compared to 'ASC + KA', 'Ex + KA', and 'KA only' group. In addition, a preventive synergistic coordination of low-intensity exercise and ASC was evident in glutathione peroxidase and superoxide dismutase activity compared to separate treatment. These results suggest that low-intensity exercise and ASC treatment have preventive effects on seizure activity and development with alternation of oxidative status. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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