| Autor: |
Ghaedi, Maryam, Steer, Catherine A., Martinez-Gonzalez, Itziar, Halim, Timotheus Y.F., Abraham, Ninan, Takei, Fumio |
| Zdroj: |
Cell Reports; Apr2016, Vol. 15 Issue 3, p471-480, 10p |
| Abstrakt: |
Summary All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s). Here, we have divided LMPPs into CD127 − (LMPP−s) and CD127 + (LMPP+s) subsets and compared them with Ly6D − and Ly6D + CLPs. Adult LMPP+s differentiated into T cells and ILCs more rapidly and efficiently than other progenitors in transplantation assays. The development of T cells and ILC2s is highly active in the neonatal period. Neonatal CLPs are rare and, unlike prominent neonatal LMPP+s, do not efficiently differentiate into T cells and ILC2s. ILC2s generated in the neonatal period are long lived and persist in adult tissues. These results suggest that some ILCs and T cells may develop from LMPP+s via CLP-independent pathways. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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