| Autor: |
Cho, Eun Yoon, Ko, Eun Sook, Han, Boo-Kyung, Kim, Rock Bum, Cho, Sooyoun, Choi, Ji Soo, Hahn, Soo Yeon |
| Předmět: |
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| Zdroj: |
Acta Radiologica; May2016, Vol. 57 Issue 5, p521-528, 8p |
| Abstrakt: |
Background: Further information is needed regarding whether histopathological characteristics affect breast tumor elasticity.Purpose: To determine whether maximum elasticity values vary according to tumor-stroma ratio, dominant stroma type, or presence of fibrosis in invasive breast cancer.Material and Methods: This study included 71 patients with invasive ductal carcinoma not otherwise specified (IDC NOS) who underwent breast shear-wave elastography (SWE). Maximum elasticity (Emax) values were retrospectively correlated with pathological findings that included tumor-stroma ratio, dominant stroma type (collagen, fibroblast, lymphocyte), and fibrosis. Multiple linear regression analysis was performed to determine variables independently associated with Emax.Results: High histologic grade was significantly correlated with higher Emax (P = 0.042). Estrogen receptor and progesterone receptor expression negatively correlated with high elasticity values (P = 0.013 and P = 0.03, respectively). Breast cancers that exhibited higher cellularity demonstrated a greater level of stiffness that was not statistically significant (ρ = 0.153; P = 0.193). While dominant stroma type and fibrosis did not affect Emax (P = 0.197 and P = 0.598, respectively), lesion size was significantly associated with Emax (ρ = 0.474, P < 0.001). On multivariate analysis, only lesion size was significantly associated with Emax (P < 0.001).Conclusion: The composition of tumors did not affect their Emax. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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