| Autor: |
Heuveis, J., Maximus, A., Bosmans, J.L., Lambert, J., De Broe, M.E. |
| Zdroj: |
Nephron (00282766); 1999, Vol. 82 Issue 1, p1-6, 6p |
| Abstrakt: |
This article focuses on renal abnormalities in psoriatic patients. Numerous systemic diseases affect both skin and kidneys. Although psoriasis is considered an immunomediated disease, it is assumed to affect the skin and joints exclusively. Psoriasis is a common chronic inflammatory disorder of the skin, which affects more than 2% of people with European ancestry. In lesioned skin, polymorphonuclear leukocytes migrate from dermal vessels into the epidermis where they may form spongiform pustules and sub conical microabcesses. Lesional psoriasis is also rich in activated cluster of differentiation (CD)4+ and CD8+ T cells, which release proinflammatory cytokines and lymphokines that stimulate keratinocyte proliferation and induce abnormal epidermal maturation. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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