| Autor: |
Meriem, Medjkane, Rachida, Allem, Housseyn, Medjahed, Farida, Taleb, Abdelaziz, Merouane, Fouzia, Mouffok |
| Předmět: |
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| Zdroj: |
Journal of Essential Oil-Bearing Plants; Mar2016, Vol. 19 Issue 2, p466-474, 9p |
| Abstrakt: |
Helicobacter pylori(H. pylori) infection plays a crucial role in the pathogenesis of gastritis, peptic ulcer, and gastric cancer. The current treatment for the eradication ofH. pyloriis unwieldy as relapses may occur. AsH. pyloricontinues to resist the present antibiotic treatments, we are challenged in attempting to find alternative treatment methods; one treatment method may be the utilization of extracted oils from plants such asPistascia lentiscus (P. lentiscus)leaves which are widely used in Mediterranean folk medicine to treat various infectious diseases, including stomach-associated diseases. Thus, this study aimed to evaluate the anti-H. pyloriactivity ofPistacia lentiscusessential oil (PLEO) obtained from leaves by hydro-distillation and analyzed by gas chromatography coupled to a mass spectrometry (GC-MS).H. pyloristrains were isolated from Algerians symptomatic patients’ gastric biopsies and characterized for their susceptibility to PLEO using both disc diffusion and agar dilution methods. Results revealed 65 components of PLEO dominated by monoterpenes, principally were α-pinene (15.47%), limonene (14.7%) and β-myrcene (9.93%). Twenty twoH. pyloristrains were isolated and their antibiotic characterization revealed that 18.18% of the tested isolates were resistant to at least two of the three antibiotics belonging to the main groups of antibiotics used in therapy to eradicateH. pylori. In contrast, PLEO showed anti-H. pyloriactivity against all the tested strains (100%). The inhibition diameters (32 mm, 26.66 mm, 19.67 and 12.33 for the pure and diluted oil to 1/2, 1/4 and 1/8) and minimum inhibitory concentration (1/5000, v/v) affirm the strong antimicrobial activity of PLEO againstH. pylori. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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