Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities.

Autor: Jafari, Elham, Khajouei, Marzieh Rahmani, Hassanzadeh, Farshid, Hakimelahi, Gholam Hossein, Khodarahmi, Ghadam Ali
Předmět:
Zdroj: Research in Pharmaceutical Sciences; Jan/Feb2016, Vol. 11 Issue 1, p1-14, 14p
Abstrakt: The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index