| Autor: |
Eason, Donna D., LeBron, Cynthia, Coppola, Domenico, Moscinski, Lynn C., Livingston, Sandra, Sutton, E. Truitt, Blanck, George |
| Předmět: |
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| Zdroj: |
Oncogene; 9/18/2003, Vol. 22 Issue 40, p6166-6176, 11p, 8 Color Photographs, 1 Black and White Photograph, 4 Charts |
| Abstrakt: |
Human lymphomas continue to represent a major challenge in oncology, and in particular occur at very high frequencies in AIDS patients. We report here the development of a CD30+ lymphoproliferative disease in mice lacking the proapoptotic transcription factor, interferon regulatory factor-1. These mice most closely represent a model of human anaplastic large-cell lymphoma (ALCL). This mouse model of lymphoma will likely be useful in understanding the development of ALCL and in understanding the development of other closely related CD30+ forms of lymphoma, such as CD30+ Hodgkin's disease and CD30+ cutaneous T-cell lymphoma. This mouse model will also be useful in testing therapies for different forms of CD30+ lymphoma, in particular anti-CD30-based therapies.Oncogene (2003) 22, 6166-6176. doi:10.1038/sj.onc.1206563 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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