The rat closely mimics oxidative stress and inflammation in humans after exercise but not after exercise combined with vitamin C administration.

Autor:	Veskoukis, Aristidis, Goutianos, Georgios, Paschalis, Vassilis, Margaritelis, Nikos, Tzioura, Aikaterini, Dipla, Konstantina, Zafeiridis, Andreas, Vrabas, Ioannis, Kyparos, Antonios, Nikolaidis, Michalis, Veskoukis, Aristidis S, Margaritelis, Nikos V, Vrabas, Ioannis S, Nikolaidis, Michalis G
Předmět:	OXIDATIVE stress PHYSIOLOGICAL stress LABORATORY rats VITAMIN C ASCORBIGENS THERAPEUTIC use of vitamin C VITAMIN therapy INFLAMMATION prevention ANIMAL experimentation EXERCISE IMMUNITY PHYSICAL fitness RATS STATISTICAL sampling VITAMINS BLIND experiment CASE-control method
Zdroj:	European Journal of Applied Physiology; Apr2016, Vol. 116 Issue 4, p791-804, 14p, 7 Graphs
Abstrakt:	Purpose: The purpose of the present study was to directly compare oxidative stress and inflammation responses between rats and humans.Methods: We contrasted rat and human oxidative stress and inflammatory responses to exercise (pro-oxidant stimulus) and/or vitamin C (anti-oxidant stimulus) administration. Vitamin C was administered orally in both species (16 mg kg(-1) of body weight). Twelve redox biomarkers and seven inflammatory biomarkers were determined in plasma and erythrocytes pre- and post-exercise or pre- and post-exercise combined with vitamin C administration.Results: Exercise increased oxidative stress and induced an inflammatory state in rats and humans. There were only 1/19 significant species × exercise interactions (catalase), indicating similar responses to exercise between rats and humans in redox and inflammatory biomarkers. Vitamin C decreased oxidative stress and increased antioxidant capacity only in humans and did not affect the redox state of rats. In contrast, vitamin C induced an anti-inflammatory state only in rats and did not affect the inflammatory state of humans. There were 10/19 significant species × vitamin C interactions, indicating that rats poorly mimic human oxidative stress and inflammatory responses to vitamin C administration. Exercise after acute vitamin C administration altered redox state only in humans and did not affect the redox state of rats. On the contrary, inflammation biomarkers changed similarly after exercise combined with vitamin C in both rats and humans.Conclusions: The rat adequately mimics human responses to exercise in basic blood redox/inflammatory profile, yet this is not the case after exercise combined with vitamin C administration. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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